Genetic Eng.

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Screening genes that can protect against Parkinson’s disease

Screening genes that can protect against Parkinson’s disease
Using a modified version of the CRISPR genome-editing system, MIT researchers have developed a new way to screen for genes that protect against specific diseases. CRISPR is normally used to edit or delete genes from living cells. However, the MIT team adapted it to randomly turn on or off distinct gene sets across large populations of cells, allowing the researchers to identify genes that protect cells from a protein associated with Parkinson’s disease.
13th October 2017

Computer program detects differences between human cells

Computer program detects differences between human cells
“How many different cell types are there in the human body? And how do these differences develop? Nobody really knows,” says Professor Stein Aerts from KU Leuven/VIB. But thanks to a new method developed by his team, that may be about to change. Even though each of the cells in our body carries the exact same DNA sequence, there’s a huge variety of cell types and functions. These differences stem from how the DNA sequence is interpreted: not all genes are ‘switched on’ in each cell.
12th October 2017

Mechanism behind ‘DNA scissor’ CRIPSR revealed

A research group at Uppsala University has found out how CRISPR-Cas9 – also known as ‘molecular scissors’ – can search the genome for a specific DNA sequence. Cas9 already has many applications in biotechnology and is also expected to revolutionise medicine. The new research findings show how Cas9 can be improved to make the molecular scissors faster and more reliable.
29th September 2017


The cyber security risks to DNA processing programs

The cyber security risks to DNA processing programs
Rapid improvement in DNA sequencing has sparked a proliferation of medical and genetic tests that promise to reveal everything from one's ancestry to fitness levels to microorganisms that live in your gut. A new study from University of Washington researchers that analysed the security hygiene of common, open-source DNA processing programs finds evidence of poor computer security practices used throughout the field.
10th August 2017

The advancement in regenerative medicine we were waiting for

The advancement in regenerative medicine we were waiting for
Researchers at The Ohio State University Wexner Medical Center and Ohio State's College of Engineering have developed a new technology, Tissue Nanotransfection (TNT), that can generate any cell type of interest for treatment within the patient's own body. This technology may be used to repair injured tissue or restore function of aging tissue, including organs, blood vessels and nerve cells.
8th August 2017

Sequencing program could enable precision medicine for advanced cancer

Sequencing program could enable precision medicine for advanced cancer
  In one of the largest and most comprehensive efforts to examine the genetic and molecular landscape of advanced cancer, researchers at the University of Michigan Comprehensive Cancer Center sequenced the DNA and RNA of 500 patients with metastatic cancer. The results are published in Nature.
3rd August 2017

How to reprogram cells in the immune system

How to reprogram cells in the immune system
When the immune system is imbalanced, either due to overly-active cells or cells that suppress its function, it causes a wide range of diseases, from psoriasis to cancer. By manipulating the function of certain immune cells, called T cells, researchers could help restore the system's balance and create new treatments to target these diseases. Scientists at the Gladstone Institutes revealed, for the first time, a method to reprogram specific T cells.
3rd August 2017

Device detects tumour cells in blood

Device detects tumour cells in blood
Researchers at the URV’s Department of Physical and Inorganic Chemistry, led by the ICREA researcher, Ramon Álvarez Puebla, and the professor of Applied Physics, Francesc Díaz, and the Department of Clinical Oncology of the HM Torrelodones University Hospital, have patented a portable device that can detect tumour cells in blood. The device counts the number of tumour cells in a blood sample in real time and is thus a highly effective tool for improving the monitoring, treatment and diagnosis of cancer.
18th July 2017

Stem cell-based therapy targets skin-to-brain cancer

Stem cell-based therapy targets skin-to-brain cancer
Investigators from Brigham and Women's Hospital (BWH) and the Harvard Stem Cell Institute have a potential solution for how to kill tumour cells that have metastasised to the brain. The team has developed cancer-killing viruses that can deliver stem cells via the carotid artery, and applied them to metastatic tumours in the brain of clinically relevant mouse models. The investigators report the elimination of metastatic skin cancer cells from the brain of these preclinical models, resulting in prolonged survival.
11th July 2017

Technique can clone thousands of genes at once

Technique can clone thousands of genes at once
Scientists at Johns Hopkins, Rutgers, the University of Trento in Italy, and Harvard Medical School report they have developed a new molecular technique called LASSO cloning, which can be used to isolate thousands of long DNA sequences at the same time, more than ever before possible. The new technology, they say, speeds up the creation of proteins, the final products of genes, and is likely to lead to far more rapid discovery of new medicines and biomarkers for scores of diseases.
5th July 2017


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