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Duke University articles

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Acoustofluidics separates exosomes from whole blood

Acoustofluidics separates exosomes from whole blood
A prototype device developed by an international team of engineers can sift exceedingly tiny particles from blood samples without having to send samples off to a lab. The device, which combines acoustic cell-sorting and microfluidic technologies, could be a boon to both scientific research and medical applications. The system is optimised to sort out “exosomes,” biological nanoparticles released from every type of cell in the body.
20th September 2017

Gold nanostars improve vaccine against cancer

Gold nanostars improve vaccine against cancer
By combining an FDA-approved cancer immunotherapy with an emerging tumour-roasting nanotechnology, Duke University researchers improved the efficacy of both therapies in a proof-of-concept study using mice. The potent combination also attacked satellite tumors and distant cancerous cells, completely curing two mice and effectively vaccinating one against the disease. The results appeared in Scientific Reports.
22nd August 2017

Artificial blood vessels simulate rare accelerated aging disease

Artificial blood vessels simulate rare accelerated aging disease
Biomedical engineers have grown miniature human blood vessels that exhibit many of the symptoms and drug reactions associated with Hutchinson-Gilford Progeria Syndrome—an extremely rare genetic disease that causes symptoms resembling accelerated aging in children. The technology will help doctors and researchers screen potential therapeutics for the disease more rapidly, with the goal of eventually creating a platform for personalised screening.
17th August 2017


Injectable solution could provide weeks of glucose control

Injectable solution could provide weeks of glucose control
  Biomedical engineers at Duke University have created a technology that might provide weeks of glucose control for diabetes with a single injection, which would be a dramatic improvement over current therapies. In primates, the treatment has been shown to last for weeks, rather than days.
6th June 2017

'Pocket colposcope' may enable self-screening

'Pocket colposcope' may enable self-screening
Duke University researchers have developed a handheld device for cervical cancer screening that promises to do away with uncomfortable speculums and high-cost colposcopes. The 'pocket colposcope' is a slender wand that can connect to many devices, including laptops or cell phones. If widely adopted, women might even use the device to self-screen, transforming screening and cure rates in low-income countries and regions of the United States, where cervical cancer is most prevalent.
1st June 2017

Lasers reveal live full-body scans of small animals

Lasers reveal live full-body scans of small animals
Biomedical engineers are now able to take a live, holistic look at the inner workings of a small animal with enough resolution to see active organs, flowing blood, circulating melanoma cells and firing neural networks. The technique dubbed 'single-impulse photoacoustic computed tomography (SIP-PACT)' uses the best of both light and ultrasound to peer inside living animals.
18th May 2017

3D printed cartilage mimics features of knee’s meniscus

3D printed cartilage mimics features of knee’s meniscus
Worn out cartilage in the knees is a major cause of disability and once it’s worn out there’s nothing ideally suited to replace it. Osteoarthritis develops,and eventually much of the entire knee is often replaced, with variable success. Researchers at Duke University have been working on creating a material that can serve as a cartilage replacement and they have already developed something at least as strong and pliable as the cartilage making up the knee’s meniscus.
24th April 2017

Mapping pathways to protective antibodies for HIV vaccine

Mapping pathways to protective antibodies for HIV vaccine
A Duke Health-led research team has described both the pathway of HIV protective antibody development and a synthetic HIV outer envelope mimic that has the potential to induce the antibodies with vaccination. "A goal for an HIV-1 vaccine is to induce broadly neutralising antibodies," said senior author Barton F. Haynes, M.D., director of the Duke Human Vaccine Institute (DHVI).
16th March 2017

Lasers measure cells’ stiffness to identify neoplastic ones

Lasers measure cells’ stiffness to identify neoplastic ones
Biomedical engineers at Duke University have discovered a way to detect signs of cancer on a cell-by-cell basis using two lasers and a camera. Several medical devices currently in use and in clinical trials around the world look for increases in cellular stiffness as an indicator of cancerous tissue. These devices, however, rely on readings from many cells clustered together within the body and cannot operate on a cellular level.
3rd March 2017

Acoustofluidic chip helps detect disease

Acoustofluidic chip helps detect disease
Scientists at Duke University have developed a way of concentrating nanoparticles inside a small device using only sound waves. This achievement may help introduce portable diagnostics that rely on attaching nanoparticles to biomarkers such as proteins and measuring how many find their targets. Nanoparticles tagged with fluorescent markers to make them easier to see are concentrated in a column by a new acoustic whirlpool device.
31st January 2017

CRISPR helps generate neuronal cells from connective tissue

CRISPR helps generate neuronal cells from connective tissue
Researchers have used CRISPR to convert cells isolated from mouse connective tissue directly into neuronal cells. In 2006, Shinya Yamanaka, a professor at the Institute for Frontier Medical Sciences at Kyoto University at the time, discovered how to revert adult connective tissue cells, called fibroblasts, back into immature stem cells that could differentiate into any cell type.
15th August 2016

Handheld device captures images with cellular resolution

Handheld device captures images with cellular resolution
  Engineers and physicians at Duke University have developed a handheld device capable of capturing images of a retina with cellular resolution. The probe will allow researchers to gather detailed structural information about the eyes of infants and toddlers for the first time.
2nd August 2016

Helping humans realise their full regenerative potential

Helping humans realise their full regenerative potential
If you trace our evolutionary tree way back to its roots -- long before the shedding of gills or the development of opposable thumbs -- you will likely find a common ancestor with the amazing ability to regenerate lost body parts. Lucky descendants of this creature, including today’s salamanders or zebrafish, can still perform the feat, but humans lost much of their regenerative power over millions of years of evolution.
7th April 2016

Monkeys drive wheelchairs using only their thoughts

Monkeys drive wheelchairs using only their thoughts
Neuroscientists at Duke Health have developed a brain-machine interface (BMI) that allows primates to use only their thoughts to navigate a robotic wheelchair. The BMI uses signals from hundreds of neurons recorded simultaneously in two regions of the monkeys’ brains that are involved in movement and sensation.
4th March 2016

Blood test can distinguish bacterial from viral infections

Blood test can distinguish bacterial from viral infections
A new test could help doctors tell whether a patient's flu-like symptoms of respiratory infection are viral or bacterial in origin, helping to avoid the overprescription of antibiotics in situations where they're not needed.
21st January 2016


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