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A*STAR articles

Displaying 1 - 11 of 11

Heart tissue grown from stem cells improves drug testing

Heart tissue grown from stem cells improves drug testing
Researchers at the Institute of Bioengineering and Nanotechnology (IBN) of A*STAR have engineered a three-dimensional heart tissue from human stem cells to test the safety and efficacy of new drugs on the heart. "Cardiotoxicity, which can lead to heart failure and even death, is a major cause of drug withdrawal from the market. Antibiotics, anticancer and antidiabetic medications can have unanticipated side effects for the heart".
12th June 2017

Scientists create blood from skin cells

Researchers in Singapore have artificially generated new mouse blood and immune cells from skin cells. This is a significant first step towards the eventual goal: the engineering of new human blood cells from skin cells or other artificial sources. One of the major challenges of regenerative medicine is to manufacture new blood and immune cells for patients in need.
21st November 2016

Nanoscale factories built to order

Nanoscale factories built to order
Performing chemical reactions inside tiny droplets can help manufacturers develop greener processes for coating drugs. A discovery led by Singapore's Agency for Science, Technology and Research (A*STAR) could lead to improvements in the way drugs are delivered to the right parts of the body by uncovering the mechanisms that help oil, water, and free radicals mix in tiny droplets.
7th November 2016


Nanoparticle drugs reach their targets with ease

Nanoparticle drugs reach their targets with ease
The huge doses of drugs required to combat cancer could be reduced thanks to the work of A*STAR researchers, and the drugs themselves may become more effective. The researchers have developed a polymeric 'scaffold' that helps drugs that often have trouble entering the bloodstream, such as anti-cancer agents, form highly stable nanoparticles with improved bioavailability.
21st October 2016

DNA-altering technology tackles diseases

DNA-altering technology tackles diseases
Researchers in Singapore have developed a protein that can alter DNA in living cells with much higher precision than current methods. The ability to alter DNA accurately will open more doors in the development of personalised medicine that could help to tackle human diseases that currently have few treatment options. Examples of diseases that have unmet therapeutic needs include neurodegenerative diseases like Huntington's disease, muscular dystrophies, and blood disorders like sickle cell anaemia.
14th September 2016

Singapore scientists grow mini human brains

Singapore scientists grow mini human brains
Scientists in Singapore have made a big leap on research on the 'mini-brain'. These advanced mini versions of the human midbrain will help researchers develop treatments and conduct other studies into Parkinson's Disease[1] (PD) and ageing-related brain diseases. These mini midbrain versions are 3D miniature tissues that are grown in the laboratory and they have certain properties of specific parts of the human brain. 
1st August 2016

A new way to diagnose and treat lung cancer

A new way to diagnose and treat lung cancer
A team of researchers from Singapore has discovered a class of small RNA molecules, known as oncomiRs, which are responsible for fuelling lung cancer. Published in Nature Communications, the findings provide fresh insight into understanding therapy resistance in lung cancer and unveil new avenues to monitor and treat the disease more effectively.
13th July 2016

A new way of looking at cancer

A new way of looking at cancer
Clusters of circulating cells commonly found in the blood of cancer patients have long been the subject of research on cancer. These clusters have been regarded for more than 50 years as malignant cells that have broken off from the primary tumour, spreading cancer to other parts of the body. 
8th July 2016

Material can kill E. Coli bacteria in just 30 seconds

Material can kill E. Coli bacteria in just 30 seconds
Every day, we are exposed to millions of harmful bacteria that can cause infectious diseases, such as the E. coli bacteria. Now, researchers at the Institute of Bioengineering and Nanotechnology (IBN) of A*STAR have developed a new material that can kill the E. coli bacteria within 30 seconds. This finding has been published in the peer-reviewed journal Small.
3rd June 2016

Sensitive biosensor for on-the-spot diagnosis of cancers

Sensitive biosensor for on-the-spot diagnosis of cancers
A compact optical device that can rapidly and sensitively detect biomarkers in urine has been developed by A*STAR researchers. It has promise for developing simple point-of-care diagnosis of cancer and other diseases. MicroRNAs are a newly discovered class of short (about 19 to 24 nuclides in length) fragments of noncoding RNAs that are useful biomarkers for diagnosing various diseases, including cardiac disease and some cancers.
9th March 2016

Surface chemistry directs crystal formation in pharmaceutical industry

Surface chemistry directs crystal formation in pharmaceutical industry
A study by A*STAR researchers suggests the surface properties of the glass vessels in which pharmaceutical ingredients are prepared has an effect on how they crystallise. When deciding how to control crystallization of an active ingredient during large scale production, drug companies consider many parameters such as solvent type, solute concentration and temperature to ensure the right crystal form.
9th March 2016


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